HETEROGENEOUS CYTOSKELETAL FORCE DISTRIBUTION DELINEATES THE ONSET CA2+ INFLUX UNDER FLUID SHEAR STRESS IN ASTROCYTES

Heterogeneous Cytoskeletal Force Distribution Delineates the Onset Ca2+ Influx Under Fluid Shear Stress in Astrocytes

Mechanical perturbations increase intracellular Ca2+ in cells, but the coupling of mechanical forces to the Ca2+ influx is not well understood.We used a microfluidic chamber driven with a high-speed pressure servo to generate defined fluid shear stress to cultured astrocytes, and simultaneously measured cytoskeletal forces using a force sensitive a

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ANALYSIS OF FREQUENCY OF PHENYLKETONURIA AMONG INSTITUTIONALIZED

Introduction: Phenylketonuria (PKU) is a genetic disease, which is caused by deficiency in phenylalanine hydroxylase (PAH) enzyme.Untreated patients will develop a severe mental retardation, which is irreversible.In this study, the incidence of the PKU disease among isolated mentally retarded residents in institutions in Isfahan, was investigated.&

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